Standard solution vs Standard Additions - What's the difference between these options of Accuracy check?

Dokument-ID

Dokument-ID TE12940

Veröffentlichungsdatum

Veröffentlichungsdatum 29.09.2021
Frage
Standard solution vs Standard Additions - What's the difference between these options of Accuracy check?
Zusammenfassung
Explanation of the differences between standard solution and standard additions accuracy check options.
Antwort
Standard solution accuracy check method checks the instrument, the reagents, and the test procedure without influence from the sample.
Standard additions accuracy check method checks all of the things the standard solution method checks, but also checks for interferences in the sample.

Which one to run depends on the goal of the accuracy check.

The standard solution method is easier to perform than standard additions. If the standard solution method passes then that confirms any measurement issues must be caused by a sample interference. If the standard solution method fails, then start by troubleshooting the test procedure, trying a different lot of reagents, or considering instrument service. If the standard solution method fails, then results on sample will also be bad. If the issue is identified through troubleshooting and the standard solution method passes after corrective action, then that will also likely resolve sample issues.

Standard additions is a more difficult procedure to perform, but if it passes then it checks all variables. If that check fails however, it can be really difficult to troubleshoot based on standard additions alone as it's difficult to know if the failure was due to a sample interference, or something else. So then you might do the standard solution method separately to verify if it's the sample or other.

If the standard solution passes but the standard additions fail then that is either a procedural issue with the standard additions procedure specifically, or a sample specific issue such as an interference. If it's an interference, in some cases dilution can be considered depending on range. Unfortunately this could indicate that the chemistry of the test is not compatible with the sample matrix and other methods should be considered.

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